Pa08g0538

Functional evidence

eggNOG

Preferred name: TRAF2 | Seed ortholog: 337451.A0A443PA53 | COG: S | eggNOG OG: BTB@131567|pg-17, BTB@1437183|DgX-27, BTB@2759|AAM-18!, BTB@3193|CdV-25

Gene Ontology

GO:0000122 negative regulation of transcription by RNA polymerase II; GO:0000228 nuclear chromosome; GO:0000242 pericentriolar material; GO:0000381 regulation of alternative mRNA splicing, via spliceosome; GO:0000781 chromosome, telomeric region; GO:0000785 chromatin; GO:0000792 heterochromatin; GO:0000793 condensed chromosome; GO:0000794 condensed nuclear chromosome; GO:0000902 cell morphogenesis; GO:0000976 transcription cis-regulatory region binding; GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding; GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding; GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific; GO:0000987 cis-regulatory region sequence-specific DNA binding; GO:0001025 RNA polymerase III general transcription initiation factor binding; GO:0001046 core promoter sequence-specific DNA binding; GO:0001161 intronic transcription regulatory region sequence-specific DNA binding; GO:0001217 DNA-binding transcription repressor activity; GO:0001222 transcription corepressor binding; GO:0001223 transcription coactivator binding; GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific; GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific; GO:0001654 eye development; GO:0001658 branching involved in ureteric bud morphogenesis; GO:0001700 embryonic development via the syncytial blastoderm; GO:0001701 in utero embryonic development; GO:0001702 gastrulation with mouth forming second; GO:0001708 cell fate specification; GO:0001755 neural crest cell migration; GO:0001764 neuron migration; GO:0001817 regulation of cytokine production; GO:0001822 kidney development; GO:0001865 NK T cell differentiation; GO:0001953 negative regulation of cell-matrix adhesion; GO:0002118 aggressive behavior; GO:0002119 nematode larval development; GO:0002244 hematopoietic progenitor cell differentiation; GO:0002394 tolerance induction in gut-associated lymphoid tissue; GO:0002467 germinal center formation; GO:0002634 regulation of germinal center formation; GO:0002711 positive regulation of T cell mediated immunity; GO:0002829 negative regulation of type 2 immune response; GO:0002903 negative regulation of B cell apoptotic process; GO:0003170 heart valve development; GO:0003279 cardiac septum development; GO:0003674 molecular_function; GO:0003677 DNA binding; GO:0003680 minor groove of adenine-thymine-rich DNA binding; GO:0003682 chromatin binding; GO:0003691 double-stranded telomeric DNA binding; GO:0003700 DNA-binding transcription factor activity; GO:0003712 transcription coregulator activity; GO:0003714 transcription corepressor activity; GO:0003723 RNA binding; GO:0005515 protein binding; GO:0005575 cellular_component; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005657 replication fork; GO:0005694 chromosome; GO:0005700 polytene chromosome; GO:0005704 polytene chromosome band; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005794 Golgi apparatus; GO:0005813 centrosome; GO:0005829 cytosol; GO:0005876 spindle microtubule; GO:0005886 plasma membrane; GO:0006110 regulation of glycolytic process; GO:0006275 regulation of DNA replication; GO:0006281 DNA repair; GO:0006325 chromatin organization; GO:0006338 chromatin remodeling; GO:0006351 DNA-templated transcription; GO:0006355 regulation of DNA-templated transcription; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006366 transcription by RNA polymerase II; GO:0006915 apoptotic process; GO:0006964 positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria; GO:0006974 DNA damage response; GO:0007010 cytoskeleton organization; GO:0007060 male meiosis chromosome segregation; GO:0007141 male meiosis I; GO:0007143 female meiotic nuclear division; GO:0007173 epidermal growth factor receptor signaling pathway; GO:0007265 Ras protein signal transduction; GO:0007266 Rho protein signal transduction; GO:0007276 gamete generation; GO:0007283 spermatogenesis; GO:0007298 border follicle cell migration; GO:0007307 eggshell chorion gene amplification; GO:0007315 germ plasm assembly; GO:0007391 dorsal closure; GO:0007398 ectoderm development; GO:0007409 axonogenesis; GO:0007411 axon guidance; GO:0007417 central nervous system development; GO:0007418 ventral midline development; GO:0007422 peripheral nervous system development; GO:0007423 sensory organ development; GO:0007424 open tracheal system development; GO:0007426 tracheal outgrowth, open tracheal system; GO:0007427 epithelial cell migration, open tracheal system; GO:0007431 salivary gland development; GO:0007435 salivary gland morphogenesis; GO:0007442 hindgut morphogenesis; GO:0007443 Malpighian tubule morphogenesis; GO:0007455 eye-antennal disc morphogenesis; GO:0007464 R3/R4 cell fate commitment; GO:0007476 imaginal disc-derived wing morphogenesis; GO:0007478 leg disc morphogenesis; GO:0007517 muscle organ development; GO:0007519 skeletal muscle tissue development; GO:0007526 larval somatic muscle development; GO:0007527 adult somatic muscle development; GO:0007530 sex determination; GO:0007548 sex differentiation; GO:0007595 lactation; GO:0007617 mating behavior; GO:0007620 copulation; GO:0008013 beta-catenin binding; GO:0008017 microtubule binding; GO:0008049 male courtship behavior; GO:0008104 intracellular protein localization; GO:0008150 biological_process; GO:0008258 head involution; GO:0008270 zinc ion binding; GO:0008284 positive regulation of cell population proliferation; GO:0008285 negative regulation of cell population proliferation; GO:0008327 methyl-CpG binding; GO:0008346 larval walking behavior; GO:0008354 primordial germ cell migration; GO:0008360 regulation of cell shape; GO:0008406 gonad development; GO:0008584 male gonad development; GO:0008595 anterior/posterior axis specification, embryo; GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage; GO:0009880 embryonic pattern specification; GO:0009953 dorsal/ventral pattern formation; GO:0010032 meiotic chromosome condensation; GO:0010428 methyl-CpNpG binding; GO:0010468 regulation of gene expression; GO:0010596 negative regulation of endothelial cell migration; GO:0010628 positive regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0010833 telomere maintenance via telomere lengthening; GO:0012501 programmed cell death; GO:0015630 microtubule cytoskeleton; GO:0016055 Wnt signaling pathway; GO:0016198 axon choice point recognition; GO:0016199 axon midline choice point recognition; GO:0016235 aggresome; GO:0016319 mushroom body development; GO:0016476 regulation of embryonic cell shape; GO:0016477 cell migration; GO:0016543 male courtship behavior, orientation prior to leg tapping and wing vibration; GO:0016544 male courtship behavior, tapping to detect pheromone; GO:0016545 male courtship behavior, veined wing vibration; GO:0016604 nuclear body; GO:0016607 nuclear speck; GO:0017053 transcription repressor complex; GO:0019901 protein kinase binding; GO:0019985 translesion synthesis; GO:0020037 heme binding; GO:0021549 cerebellum development; GO:0021766 hippocampus development; GO:0021903 rostrocaudal neural tube patterning; GO:0021954 central nervous system neuron development; GO:0021987 cerebral cortex development; GO:0030036 actin cytoskeleton organization; GO:0030054 cell junction; GO:0030097 hemopoiesis; GO:0030178 negative regulation of Wnt signaling pathway; GO:0030183 B cell differentiation; GO:0030217 T cell differentiation; GO:0030223 neutrophil differentiation; GO:0030282 bone mineralization; GO:0030308 negative regulation of cell growth; GO:0030510 regulation of BMP signaling pathway; GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway; GO:0030536 larval feeding behavior; GO:0030539 male genitalia development; GO:0030540 female genitalia development; GO:0030707 follicle cell of egg chamber development; GO:0030853 negative regulation of granulocyte differentiation; GO:0030878 thyroid gland development; GO:0030890 positive regulation of B cell proliferation; GO:0031104 dendrite regeneration; GO:0031208 POZ domain binding; GO:0031463 Cul3-RING ubiquitin ligase complex; GO:0031490 chromatin DNA binding; GO:0031503 protein-containing complex localization; GO:0031507 heterochromatin formation; GO:0031519 PcG protein complex; GO:0031625 ubiquitin protein ligase binding; GO:0031965 nuclear membrane; GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process; GO:0032481 positive regulation of type I interferon production; GO:0032728 positive regulation of interferon-beta production; GO:0032740 positive regulation of interleukin-17 production; GO:0032755 positive regulation of interleukin-6 production; GO:0032760 positive regulation of tumor necrosis factor production; GO:0032764 negative regulation of mast cell cytokine production; GO:0032825 positive regulation of natural killer cell differentiation; GO:0032868 response to insulin; GO:0032991 protein-containing complex; GO:0032993 protein-DNA complex; GO:0033077 T cell differentiation in thymus; GO:0033696 heterochromatin boundary formation; GO:0034504 protein localization to nucleus; GO:0034644 cellular response to UV; GO:0035001 dorsal trunk growth, open tracheal system; GO:0035024 negative regulation of Rho protein signal transduction; GO:0035035 histone acetyltransferase binding; GO:0035041 sperm DNA decondensation; GO:0035147 branch fusion, open tracheal system; GO:0035151 regulation of tube size, open tracheal system; GO:0035191 nuclear axial expansion; GO:0035220 wing disc development; GO:0035297 regulation of Malpighian tubule diameter; GO:0035556 intracellular signal transduction; GO:0035861 site of double-strand break; GO:0035883 enteroendocrine cell differentiation; GO:0040003 chitin-based cuticle development; GO:0040011 locomotion; GO:0042074 cell migration involved in gastrulation; GO:0042092 type 2 immune response; GO:0042098 T cell proliferation; GO:0042127 regulation of cell population proliferation; GO:0042162 telomeric repeat DNA binding; GO:0042332 gravitaxis; GO:0042382 paraspeckles; GO:0042675 compound eye cone cell differentiation; GO:0042682 regulation of compound eye cone cell fate specification; GO:0042789 mRNA transcription by RNA polymerase II; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0042826 histone deacetylase binding; GO:0042981 regulation of apoptotic process; GO:0043035 chromatin insulator sequence binding; GO:0043065 positive regulation of apoptotic process; GO:0043066 negative regulation of apoptotic process; GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process; GO:0043249 erythrocyte maturation; GO:0043370 regulation of CD4-positive, alpha-beta T cell differentiation; GO:0043372 positive regulation of CD4-positive, alpha-beta T cell differentiation; GO:0043376 regulation of CD8-positive, alpha-beta T cell differentiation; GO:0043377 negative regulation of CD8-positive, alpha-beta T cell differentiation; GO:0043380 regulation of memory T cell differentiation; GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator; GO:0043565 sequence-specific DNA binding; GO:0044877 protein-containing complex binding; GO:0045066 regulatory T cell differentiation; GO:0045111 intermediate filament cytoskeleton; GO:0045138 nematode male tail tip morphogenesis; GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity; GO:0045433 male courtship behavior, veined wing generated song production; GO:0045444 fat cell differentiation; GO:0045467 R7 cell development; GO:0045476 nurse cell apoptotic process; GO:0045496 male analia development; GO:0045497 female analia development; GO:0045500 sevenless signaling pathway; GO:0045582 positive regulation of T cell differentiation; GO:0045591 positive regulation of regulatory T cell differentiation; GO:0045596 negative regulation of cell differentiation; GO:0045600 positive regulation of fat cell differentiation; GO:0045619 regulation of lymphocyte differentiation; GO:0045629 negative regulation of T-helper 2 cell differentiation; GO:0045649 regulation of macrophage differentiation; GO:0045650 negative regulation of macrophage differentiation; GO:0045656 negative regulation of monocyte differentiation; GO:0045666 positive regulation of neuron differentiation; GO:0045670 regulation of osteoclast differentiation; GO:0045677 negative regulation of R7 cell differentiation; GO:0045746 negative regulation of Notch signaling pathway; GO:0045786 negative regulation of cell cycle; GO:0045821 positive regulation of glycolytic process; GO:0045892 negative regulation of DNA-templated transcription; GO:0045893 positive regulation of DNA-templated transcription; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0046332 SMAD binding; GO:0046426 negative regulation of receptor signaling pathway via JAK-STAT; GO:0046533 negative regulation of photoreceptor cell differentiation; GO:0046628 positive regulation of insulin receptor signaling pathway; GO:0046660 female sex differentiation; GO:0046661 male sex differentiation; GO:0046843 dorsal appendage formation; GO:0046889 positive regulation of lipid biosynthetic process; GO:0046982 protein heterodimerization activity; GO:0048047 mating behavior, sex discrimination; GO:0048053 R1/R6 development; GO:0048060 negative gravitaxis; GO:0048065 male courtship behavior, veined wing extension; GO:0048070 regulation of developmental pigmentation; GO:0048071 sex-specific pigmentation; GO:0048086 negative regulation of developmental pigmentation; GO:0048092 negative regulation of male pigmentation; GO:0048294 negative regulation of isotype switching to IgE isotypes; GO:0048477 oogenesis; GO:0048538 thymus development; GO:0048626 myoblast fate specification; GO:0048666 neuron development; GO:0048702 embryonic neurocranium morphogenesis; GO:0048750 compound eye corneal lens morphogenesis; GO:0048813 dendrite morphogenesis; GO:0048821 erythrocyte development; GO:0048872 homeostasis of number of cells; GO:0050681 nuclear androgen receptor binding; GO:0050727 regulation of inflammatory response; GO:0050767 regulation of neurogenesis; GO:0050776 regulation of immune response; GO:0051141 negative regulation of NK T cell proliferation; GO:0051216 cartilage development; GO:0051252 regulation of RNA metabolic process; GO:0051260 protein homooligomerization; GO:0051302 regulation of cell division; GO:0051402 neuron apoptotic process; GO:0051493 regulation of cytoskeleton organization; GO:0051726 regulation of cell cycle; GO:0055088 lipid homeostasis; GO:0060042 retina morphogenesis in camera-type eye; GO:0060179 male mating behavior; GO:0060446 branching involved in open tracheal system development; GO:0060766 negative regulation of androgen receptor signaling pathway; GO:0060976 coronary vasculature development; GO:0061024 membrane organization; GO:0061040 female gonad morphogenesis; GO:0061059 positive regulation of peptidoglycan recognition protein signaling pathway; GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding; GO:0070314 G1 to G0 transition; GO:0070418 DNA-dependent protein kinase complex; GO:0070530 K63-linked polyubiquitin modification-dependent protein binding; GO:0071333 cellular response to glucose stimulus; GO:0072562 blood microparticle; GO:0090336 positive regulation of brown fat cell differentiation; GO:0090575 RNA polymerase II transcription regulator complex; GO:0090721 primary adaptive immune response involving T cells and B cells; GO:0097680 double-strand break repair via classical nonhomologous end joining; GO:0098531 ligand-modulated transcription factor activity; GO:0120162 positive regulation of cold-induced thermogenesis; GO:0140297 DNA-binding transcription factor binding; GO:0140588 chromatin looping; GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage; GO:1902254 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator; GO:1902275 regulation of chromatin organization; GO:1902622 regulation of neutrophil migration; GO:1902667 regulation of axon guidance; GO:1903464 negative regulation of mitotic cell cycle DNA replication; GO:1903688 positive regulation of border follicle cell migration; GO:1905521 regulation of macrophage migration; GO:1990830 cellular response to leukemia inhibitory factor; GO:1990837 sequence-specific double-stranded DNA binding; GO:1990845 adaptive thermogenesis; GO:2000147 positive regulation of cell motility; GO:2000176 positive regulation of pro-T cell differentiation; GO:2000320 negative regulation of T-helper 17 cell differentiation; GO:2000640 positive regulation of SREBP signaling pathway; GO:2000677 regulation of transcription regulatory region DNA binding; GO:2000773 negative regulation of cellular senescence; GO:2001199 negative regulation of dendritic cell differentiation; GO:2001200 positive regulation of dendritic cell differentiation

KEGG

EC: ec:1.2.1.16, ec:1.2.1.20, ec:1.2.1.79 | KO: K00135, K02174, K09042, K09191, K09228, K09237, K10055, K10456, K10457, K10468, K10477, K10478, K10484, K10486, K10488, K10489, K10490, K10491, K10492, K10493, K10494, K10495, K10496, K10497, K10498, K10499, K10500, K10501, K10502, K10503, K10504, K10505, K10506, K10507, K10508, K10509, K10510, K10511, K10512, K10513, K10514, K10515, K10516, K10517, K10518, K10519, K10523, K12498, K14972, K15618, K22402, K22499, K22648, K23196, K24383, K24384, K24385, K24804, K24805, K24806, K24807, K24810 | Pathway: 00250, 00310, 00350, 00650, 00760, 01100, 03460, 04013, 04068, 04110, 04120, 04214, 04320, 04341, 05012, 05200, 05202, 05207, 05208, 05221, 05222, 05225, 05418 | Module: M00027, M00956, M00957 | BRITE: 00001, 01000, 01009, 03000, 03021, 03036, 03400, 04121, 04990